Subsequent extravasation of plasma proteins forms a provisional scaffold for endothelial cell migration, facilitated by secretion of matrix metalloproteinases and angiopoietin-2 which degrade the extracellular matrix (ECM) and liberate further growth factors. Normally, angiogenic stimulation results in nitric oxide dependent vasodilatation and increased vascular permeability in response to vascular endothelial growth factor (VEGF). Defined as formation of new capillaries from pre-existing blood vessels, this key component of the proliferative phase gives rise to vasculature forming up to 60% of granulation tissue. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.Īngiogenesis is a crucial mechanism during wound healing involving the dynamic co-ordinated interaction of structural, cellular and molecular components. There are no further patents, products in development or marketed products to declare. Integra Matrix Wound Dressing samples were kindly provided by Integra LifeSciences (Plainsboro, NJ, USA). The trial involves a National Health Service Blood and Transplant (Watford, UK) derived product that has been licensed to Tissue Regenix. The remainder of the funds for this study were sourced from existing internal budgets.Ĭompeting interests: Tissue Regenix plc provided funding towards this study. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are creditedĭata Availability: All relevant data are within the paper and its Supporting Information files.įunding: This study was in part funded by the Tissue Regenix Group plc (York, UK) to AB. Received: AugAccepted: OctoPublished: January 20, 2015Ĭopyright: © 2015 Greaves et al. University of New Mexico HSC, UNITED STATES OF AMERICA Citation: Greaves NS, Morris J, Benatar B, Alonso-Rasgado T, Baguneid M, Bayat A (2015) Acute Cutaneous Wounds Treated with Human Decellularised Dermis Show Enhanced Angiogenesis during Healing.
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